Search results for key=SMA2020 : 1 match found.

2020

• @article{SMA2020,
  	vgclass =	{refpap},
  	author =	{Squire, David McG.\ and Motyer, Allan and Ahn, Richard and Nititham, Joanne and Huang, Zhi-Ming and Oksenberg, Jorge R.\ and Foerster, John and Liao, Wilson and Leslie, Stephen},
  	title =	{{MHC*IMP} -- Imputation of Alleles for Genes in the Major Histocompatibility Complex},
  	journal =	{bio{R}xiv},
  	year =	{2020},
  	note =	{(preprint)},
  	doi =	{https://doi.org/10.1101/2020.01.24.919191},
  	abstract =	{We report the development of MHC*IMP, a method for imputing
    non-classical HLA and other genes in the human Major Histocompatibility
    Complex (MHC). We created a reference panel for 25 genes in the MHC using
    allele calls from Whole Genome Sequencing data, combined with SNP data
    for the same individuals. We used this to construct an allele imputation
    model, MHC*IMP, for each gene. Cross-validation showed that MHC*IMP
    performs very well, with allele prediction accuracy 93\% or greater for
    all but two of the genes, and greater than 95\% for all but four.},
  }